1 May 2023Article
The effect of fundectomy on histopathological findings and metabolic hormones in rats
Nihat Bugdayci 1Talar Aktokmakyan 2Merve Tokocin 1Serhat Meric 1Gulcin Ercan 1Aysegul Kirankaya 3Tugce Cay 4Ferda Koksoy 5Osman Gulcicek 1Atilla Celik 1
Affiliations
Article Info
1 Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey
2 Department of General Surgery, Istinye University, School of Medicine, Istanbul, Turkey
3 Department of Medical Biochemistry, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey
4 Department of Pathology, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey
5 Department of General Surgery, Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
Ann. Ital. Chir., 2023, 94(3), 309-315;
Published: 1 May 2023
Copyright © 2023 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
AIM: Fundectomy, shown as an alternative to restrictive techniques, causes absorption restriction and metabolic changes. This study aimed to examine the histopathological changes caused by the fundectomy as a technique applied to rats by hormones that affect stomach and obesity metabolism and its effect on weight loss. MATERIAL AND METHODS: 2randomly selected Winstar-Hannover rat groups were evaluated by measuring their pre-and postoperative weights and biochemically measuring Gastrin, Ghrelin, and Leptin levels on day 30. After sacrification, the stomachs were taken for histopathological examination. RESULTS: Significant weight loss was observed in the fundectomy group in the 1stmonth postoperatively. Biochemically, Gastrin means in the fundectomy group were statistically significantly higher than in the control group. The mean Ghrelin and Leptin levels of the Fundectomy Group were statistically significantly lower (p=0.005). Immunohistochemically, Gastrin means ™at the antrum and proximal stomach parts of the Fundectomy Group were significantly higher than in the control group. As Ghrelin, a significant decrease was observed in all 3regions of the Fundectomy Group compared to the control group. Leptin results were significantly lower at the antrum and proximal stomach parts of the Fundectomy Group. Histopathologically, in the Fundectomy Group, cystic glandular hyperplasia was moderate at the proximal stomach, foveolar hyperplasia was mild at the antrum, fibrosis was moderate at the antrum and corpus, and high at the proximal stomach. CONCLUSION: Fundectomy is an effective method in terms of weight loss. This animal experiment, conducted as a pilot study, will be an essential step in elucidating metabolic and histopathological changes.
Keywords
- Bariatric surgery
- Fundectomy
- Obesity