Background: Laparoscopic appendectomy has gained prominence in the management of acute appendicitis, necessitating secure closure of the appendiceal stump. Two common techniques for this purpose are Hem-o-lok clips (HC) and endoloops (EL), each offering distinct advantages. Aims: This retrospective study aimed to compare the outcomes of the HC and EL closure techniques. Specifically, the study focused on postoperative complications, hospital stays, and readmission rates. Materials and Methods: A retrospective database review was conducted from November 2022 to August 2023. The study compared outcomes, postoperative complications, and the length of hospital stay in 123 patients who underwent appendiceal stump closure with HC and EL at the General Surgery Department of the Turkish Hospital in Doha, Qatar. Results: Among the 123 patients who underwent laparoscopic appendectomy, appendiceal stump closure was performed with HC in 50 patients and EL in 73 patients. Six patients experienced infectious complications associated with the procedure. The hospital stays were similar in both groups (Group HC: 1.3 ± 2 days, Group EL: 1.4 ± 2 days), and there were two readmissions in each group. Conclusion: The study supports the equivalence of HC and EL closure techniques. Both methods demonstrate comparable postoperative complications, hospital stays, and readmission rates. Surgeons can make informed decisions based on patient profiles and available resources.