1 Jan 2011Review
Pathology of dysplasia and cancer in inflammatory bowel disease
Claudia Mescoli 1Mauro Frego 2Massimo Rugge 1
Affiliations
Article Info
1 Dept. of Diagnostic Medical Sciences & Special Therapies; Surgical Pathology & Cytopathology Unit, University of Padua, Italy
2 Dept. of Surgical & Gastroenterological Sciences “PG. Cévese”, University of Padua, Italy
Ann. Ital. Chir., 2011, 82(1), 11-18;
Published: 1 Jan 2011
Copyright © 2011 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
In both Crohn’s disease and Ulcerative Colitis, Colorectal Cancer (CRC) secondary prevention basically relies on the histology detection of dysplasia. In Inflammatory Bowel Diseases (IBD) setting, dysplasia identifies the subgroup of patients eligible to a (more) strict surveillance program (or prophylactic colectomy). In the clinical practice, a number of issues might affect the benefit of the clinico-pathological surveillance of the IBD-dysplasia-patients: sampling errors, inconsistency in biopsy assessment, patients’ drop-out, etc. Even in such a multifaceted context, evidence has been provided that surveillance of dysplasia is effective in reducing both CRC mortality and morbidity. This manuscript focuses on current issues concerning the histology assessment of the IBD-associated dysplastic lesions.
Keywords
- Colorectal cancer
- Dysplasia
- IBD