Gastric medullary carcinoma. A case report and review of the literature

Abstract

 

Medullary gastric carcinoma (MGC) is a rare gastric neoplasm characterized by the histological appearance of dense lymphocytic infiltration of the stroma. The prevalence of MGC among all gastric neoplasms is about 1%. Although it is classified within the poorly differentiated carcinomas, the biological activity of MGC is similar to that of the well-differentiated carcinomas. Hereby, we present a case of a 64-year-old male patient who underwent upper gastrointestinal (GI) endoscopy for abdominal pain over the last 2 months. The pathological findings of the GI endoscopy specimen revealed adenocarcinoma of the stomach. Subsequently, the patient underwent total gastrectomy and D2 lymph node dissection. Pathological evaluation of the excised specimens samples was compatible with MGC (gastric carcinoma with lymphoid stroma) which was staged as T2N0M0. This paper purposed to describe the clinical and pathological findings of MGC.