Association between neuroendocrine tumor of the ileum and two colonic primary malignancies

Luca  Napolitano; Valentina  D’Alessandro; Domenico  Risio; Camilla  Marinelli; Roberta  Cianci; Paolo  Innocenti

doi:pii/660

4 Oct 2017Case Report

Association between neuroendocrine tumor of the ileum and two colonic primary malignancies

Luca Napolitano ¹Valentina D’Alessandro ¹Domenico Risio ¹Camilla Marinelli ²Roberta Cianci ³Paolo Innocenti ¹

Affiliations

Article Info

¹ Unit of General and Laparoscopic Surgery, “G. d’Annunzio” University, Chieti, Italy

² Unit of Pathology, “G. d’Annunzio” University, Chieti, Italy

³ Department of Neurosciences and Imaging, Section of Radiological Imaging, ‘‘G. d’Annunzio’’ University, Chieti, Italy

Abstract

BACKGROUND: A high rate of association between neuroendocrine tumors (NETs) and secondary primary malignancy (SPM) has been described in literature and this association can occur either in a synchronous or a metachronous presentation. A wide range of hypothesis has been postulated to explain the high rate of association between NETs and SPM, without definitive conclusions. CASE PRESENTATION: We report a case of an ileal neuroendocrine tumor found incidentally at the histologic examination of the surgical specimen in a 72 years old male underwent to right hemi colectomy for two colic adenomatous polips with high grade dysplasia. CONCLUSION: Large multicentric epidemiological studies should be considered to assess the association between NETs and SPM.

Keywords

Neuroendocrine tumors (NETs)
Progression-Free Survival (PFS)
Secondary primary malignancy (SPM)