The effect of hepatic ischemia in the liver of rats with obstructive jaundice

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Published: May 1, 2020
Keywords:
Dilatation of sinusoids, Granulocytes infiltration, Oxaloxate, Pyruvate transaminase, Transaminase reperfusion

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Charalambos Odisseos
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Orestis Ioannidis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Christos Chatzakis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Savvas Symeonidis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Stefanos Bitsianis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Panagiotis Christidis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Lydia Loutzidou
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Ioannis Mantzoros
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Efstathios Kotidis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Manousos George Pramateftakis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Stamatios Angelopoulos
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Konstantinos Tsalis
Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Abstract

OBJECTIVE: The aim of the current study was to evaluate the effect of ischemia-reperfusion injury on the liver’s function and morphology during the establishment and progress of obstructive jaundice.


MATERIAL AND METHODS: 80 Wistar rats were used for the purposes of the study and were allocated in four groups: JAUNDICE (obstructive jaundice), JAUN-ISC (obstructive jaundice and ischemia reperfusion), CONTROL (laparotomy) and ISCHEMIA (ischemia reperfusion).


RESULTS: Obstructive jaundice, and ischemia-reperfusion injury following obstructive jaundice led to increased mortality, while no mortality was noticed in the control and ischemia groups. In the JAUN-ISC group, SGOT was significantly increased on the 10th day and SGPT was significantly increased on the 1st day compared to JAUNDICE group. Moreover, in the JAUN-ISC group, sinusoid dilation was significantly increased on the 5th and 10th days and neutrophil infiltration was significantly increased on the 10th day compared to the JAUNDICE group.


CONCLUSIONS: A mild ischemia-reperfusion injury that in the normal liver led only to slight increase of hepatic neutrophil infiltration in the presence of obstructive jaundice led to increased hepatic biochemical markers (SGOT, SGPT) and increased hepatic sinusoid dilatation and enhanced neutrophil infiltration.

Article Details

How to Cite
Odisseos, Charalambos, et al. “The Effect of Hepatic Ischemia in the Liver of Rats With Obstructive Jaundice”. Annali Italiani Di Chirurgia, vol. 91, no. 3, May 2020, pp. 334-4, https://annaliitalianidichirurgia.it/index.php/aic/article/view/1969.
Issue
Vol. 91 No. 3 (2020)
Section
Article