Orally-applied hazelnut extract accelerates wound healing in the early period. An experimental study in rats

Abstract

AIM: The aim of this study was to evaluate the effect of oral and local use of hazelnut extract on wound healing on different periods.

MATERIAL OF STUDY: 72 male Wistar-Albino rats were used in this study. The rats were divided into 9 groups with similar weights. According to the days (3; 7; 14) and administration of hazelnut groups were formed as oral (3O, 7O, 14O), local (3L, 7L, 14L) and control (3C, 7C, 14C) groups. Under anesthesia 1 cm length wound was formed in the back regions of the rats and surgically repaired with sutures. Rats were sacrificed at 3th, 7th and 14th days and samples were obtained from the surgical regions. Histopathological analyzes were performed according to the wound healing scoring system.

RESULTS: According to the histopathological analysis, re-epithelization and collogen organization wound healing scores were significantly superior in the group 30 when compared to other groups (re-epithelization p=0.002, collogen organization p=0.003).

DISCUSSION: The most important finding explored in this study is that orally administered hazelnut accelerated wound healing in the early period. It is thought that this effect is achieved due to antioxidant substances contained in hazelnut by increasing the re-epithelization and collogen organization and preventing free radicals formed during wound healing.

CONCLUSION: In this study it was determined that oral nutrition accelerated wound healing in the early period. However, further immunohistochemical and biomechanical studies are needed to support these results.