USE OF PROGNOSTIC AND PREDICTIVE FACTORS IN THE MANAGEMENT OF BREAST CANCER PATIENTS

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F. PUGLISI
C. DI LORETO
C.A. BELTRAMI

Abstract

Numerous pathologic and biologic factors have been asses sed for their ability to predict clinical behaviour and respon se to therapy in breast cancer patients. Currently, traditio nal morphological features such as lymph node status, tumour size, histological type and tumour grade remain the leading prognostic factors. Steroid receptors are also impor tant, but their main role consists in predicting response to hormonal therapy. Although several new indicators have been proposed to refine the value of the above-mentioned proven parameters, interpretation of their impact is not con clusive. In particular, immunohistochemical evaluation of p53, c-erbB-2 and MIB-1 appears to be potentially useful and considerable efforts are currently being made to tech nically and clinically validate them.

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How to Cite
PUGLISI, F., et al. “USE OF PROGNOSTIC AND PREDICTIVE FACTORS IN THE MANAGEMENT OF BREAST CANCER PATIENTS”. Annali Italiani Di Chirurgia, vol. 70, no. 3, May 1999, pp. 335-42, https://annaliitalianidichirurgia.it/index.php/aic/article/view/3218.
Section
Editorial