Gastric mixed adeno-neuroendocrine carcinoma with a large cell neuroendocrine component A case reports

Abstract

Digestive system carcinomas containing a neuroendocrine and an exocrine component are classiied as mixed adenoneuroendocrine carcinomas(manec), as one of the component represents at least 30% of the whole lesion. We herein aim to contribute to literature by presenting our rare case of gastric manec. A 58-year-old male patient had a 3 cm mass placed in the antrum in his gastroscopy. he biopsy result was signet ring cell carcinoma. After that total gastrectomy with d2 lymph node dissection and roux-en-y oesophagojejunostomy was performed. he histopathology result was signet ring cell and mucinous adenocarcinoma with large cell neuroendocrine carcinoma component(manec). Manec, a rare type of biphasic tumor, usually has a poor prognosis regardless of its stage and location. his behavior is thought to be caused by the neuroendocrine component. It is vital to know the histopathology of the tumor in order to provide certain standards diagnosis and treatment management.